Diamorphine toxicity

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Extradural diamorphine with adrenaline in labour: comparison with diamorphine and bupivacaine.

In a randomized double-blind study of 51 primigravida, we have examined the relative efficacies of bupivacaine, diamorphine or diamorphine with adrenaline given by the extradural route for relief of pain during labour. Group 1 (n = 18) received diamorphine 5 mg in 0.9% sodium chloride 8 ml; group 2 (n = 19) received diamorphine 5 mg in 0.9% sodium chloride 8 ml with 1:200,000 adrenaline; group ...

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Accidental intrathecal administration of high dose diamorphine.

A case of accidental administration of high dose intrathecal diamorphine is reported in a patient who underwent total knee replacement. Initially a regional technique was planned for this patient, but due to inadvertent administration of three milligrams of diamorphine intrathecally, it was decided to convert the patient to have a general anaesthetic. Postoperatively, she was monitored in high ...

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Stumbling blocks in the study of diamorphine.

Although the centenary of the discovery ofdiamorphine is soon to be celebrated, much work remains to be done before its mode of action is thoroughly understood. The main stumbling blocks facing the would-be investigator can be summarized as follows: (1) Diamorphine in solution has a limited shalf-life. (2) The potency ratio of diamorphine to morphine is still a matter of dispute. (3) No basic s...

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Diamorphine infusion in the preterm neonate.

The effects of diamorphine were studied in 34 premature neonates who were given a loading dose of 50 micrograms/kg of diamorphine followed by a constant rate intravenous infusion of 15 micrograms/kg/hour. Small but significant falls were noted in blood pressure (at 30 minutes) and heart rate (at 30 minutes, six hours, and 12 hours) after administration of diamorphine, but these did not appear t...

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Extradural diamorphine in the control of pain following lumbar laminectomy.

Catheters were inserted into the extradural space under direct vision at the time of surgery for prolapsed intervertebral disc or lumbar canal stenosis. In the post-operative period, diamorphine (3 mg in 5 ml water) was injected through the catheter when patients requested analgesia. In only four of 49 patients was significant pain relief not achieved after extradural diamorphine injection. In ...

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ژورنال

عنوان ژورنال: Anaesthesia

سال: 1992

ISSN: 0003-2409,1365-2044

DOI: 10.1111/j.1365-2044.1992.tb02026.x